CTH and early-onset autosomal dominant Alzheimer disease: CTH was linked to a number of diseases and conditions such as Alzheimer's disease (Østergaard et al., 2013a), stroke-like symptoms (Østergaard et al., 2013b), traumatic brain injury (Østergaard et al., 2014a) and ischemic heart disease (Ostergaard et al., 2014b).