CTH and early-onset autosomal dominant Alzheimer disease: This has potential implications in the study of all conditions where capillary dysfunction and CTH are thought to be involved, such as Alzheimer's disease (Østergaard et al., 2013a), stroke (Østergaard et al., 2015), traumatic brain injury (Østergaard et al., 2014a) and ischemic heart disease (Ostergaard et al., 2014b).