Yet, this indicates an earlier onset of vascular repair mechanisms which is particularly relevant owing to the fact that Angiopoietin-2 is only expressed at sites of vascular remodeling (Maisonpierre et al., 1997) and that application of synthetic Tie-2 agonistic peptide (Rubig et al., 2016) as well as VEGF (Kang et al., 2001) protects renal vascular function in experimental AKI. This evidence concerns the gene VEGFA and acute kidney injury.