Since synaptic connectivity is reduced in frontal cortex in AD and DLB (Jellinger, 2000; Selkoe, 2002; Hashimoto and Masliah, 2003; Gong and Lippa, 2010; Schulz-Schaeffer, 2010; Ferrer, 2012; de Wilde et al., 2016; Santpere et al., 2017), the possibility of reduced GLT1 expression secondary to decreased synaptic activity must not be overlooked in AD and DLB. Here, SLC1A2 is linked to Lewy body dementia.