Reports indicate that anxiety and other behavioral symptoms are more prominent and severe in the population of female AD patients who are APOE-ε4 carriers (Steinberg et al., 2006; Xing et al., 2015), thereby supporting the notion of a relationship between the interaction of APOE-ε4 and gender in the phenotypical shaping of the AD-related behavioral features. This evidence concerns the gene APOE and Alzheimer disease.