Agreeing with the role of alpha-synuclein at presynapses (Lashuel et al., 2013), several genes annotated for the Gene Ontology-slim term synapse showed differential expression, some of them previously associated with Parkinson's disease including Nptx2, Wnt7a, and Rims3 (Figure 1B) (Moran et al., 2008; Simunovic et al., 2009; Inestrosa and Arenas, 2010). Here, RIMS3 is linked to Parkinson disease.