We have previously demonstrated that AMBRA1-induced mitophagy is able to trigger mitophagy in fibroblasts from PD patients bearing PINK1 or PARKIN mutations, this highlighting the fact that AMBRA1 can serve as an alternative mediator of mitophagy to maintain mitochondrial turnover in PINK1/PARKIN-related PD. This evidence concerns the gene AMBRA1 and Parkinson disease.