This assumption is based on specific SCAs present in hetMNA but not in homMNA tumours26,28 and the presence of ATRX intragenic deletions in hetMNA tumours, not so far detected, in homMNA tumours28 and is further supported by the lack of homMNA relapses in patients >18 months at diagnosis (shown in Table 2). This evidence concerns the gene ATRX and neoplasm.