ATRX and neoplasm: The latter is the case for intragenic deletions of the ATRX gene.28 Also the outcome of hetMNA patients with localised disease differed as compared to homMNA patient: data from the LNESG1 cohort showed that five of the seven stage 1 homMNA tumour patients without upfront cytotoxic treatment experienced a relapse and four patients died of disease.52 By contrast, none of the 13 stage 1 hetMNA patients showed a relapse (10 patients without upfront cytotoxic treatment, 3 patients with conventional chemotherapy).