AKT1 and Familial prostate cancer: Next, we determined whether pharmacological inhibition of β-catenin would inhibit enhanced transendothelial migration of human DU145 prostate cancer cells through Akt1-deficient HLEC monolayer in vitro and limit lung colonisation of murine RM1 prostate cancer cells in VECad-Cre-Akt1 mice in vivo.