AKT1 and cancer: Although a number of clinical trials have been performed on the use of Akt inhibitors for cancer therapy, none has been approved so far and many studies have shown to further worsen the condition.26–31 As of today, the role of endothelial Akt1 in cancer metastasis and the effect of endothelial Akt1 loss on tumour growth and metastasis have not been studied.