BRAF and neoplasm: It is well-known that the selective BRAF inhibitors vemurafenib and dabrafenib reduce cell proliferation by suppressing ERK phosphorylation in tumours with BRAF V600E only.21 However, in this study, ERK phosphorylation was inhibited after AZ304 treatment in cell lines and tumour tissues bearing both V600E and wild type BRAF genes.