IFNG and neoplasm: We next explored the ability of intratumoral Ad-RTS-mIL-12 at 5 × 109+oral veledimex 1 to 30 mg/m2 to locally produce IL-12 and downstream IFN-γ in the tumor, as well as assess serum IL-12 and IFN-γ levels in the GL-261 orthotopic syngeneic mouse model.