To this end, we monitored cohorts of Pole4+/+p53+/−, Pole4−/−p53−/−, Pole4+/+p53−/−, and Pole4−/−p53−/− mice for ∼18 months and performed a Kaplan-Meier analysis to assess lymphoma-free survival (Figure 6F). This evidence concerns the gene TP53 and lymphoma.