POLE and neoplasm: Moreover, mutations of POLE1 in proximity to the proofreading exonuclease domain have been identified in several neoplasias such as colorectal and endometrial cancer, which are associated with a peculiar hypermutator phenotype (Alexandrov et al., 2013, Campbell et al., 2017, Kandoth et al., 2013, Yang et al., 2013).