POLE4 and lymphoma: Pole4 deficiency did not lead to a reduction in lifespan (Figure 1J) but did result in increased incidence of lymphomas in the thymus (around 12% of Pole4-deficient mice compared to 4% WT mice) and mesenteric lymph nodes (23.5% in Pole4−/− versus 7.7% in WT; Figure 1K).