HLA-DRB1*01 was also negatively associated with repetitive regions of P. vivax MSP-9 antigen in the Brazilian Amazon, and HLA-DQB1*05 along with HLA-DRB1*13 has been associated with a reduced susceptibility to severe malaria in Gambian children [28, 51, 54]. This evidence concerns the gene HLA-DRB1 and malaria.