The Src kinase is a non‐receptor tyrosine kinase and was involved in regulating malignant behaviours in tumour cells,49, 50 whereas recently, Fak/Src signalling was shown to mediate the effects of ZEB1‐induced extracellular matrix degradation and in turn to enhance lung cancer invasion and metastasis.21 Thus, the current study assessed whether the Src signalling regulated ZEB1‐induced VM formation. Here, PTK2 is linked to lung cancer.