ZEB1 and Src kinase were shown to modulate PCa cell metastatic phenotypes.35 Hence, we investigated whether Src contributed to ZEB1‐dependent VM formation and found that ZEB1 knockdown down‐regulated the level of p‐Src527 in both PC3 and DU‐145 cell lines but dramatically enhanced the level of p‐Src416 in PC3 and decreased level of p‐Src416 in DU‐145 (Figure 5A). This evidence concerns the gene ZEB1 and posterior cortical atrophy.