TP53 and skin neoplasm: However, our previous study (Mikheev et al., 2017), the present study, and others (Burns et al., 2013) demonstrate that TW can support tumorigenicity independent of p53 mutational status and as shown in a mouse model of skin cancer (Beck et al., 2015), TW may have p53‐dependent and p53‐independent functions that drive malignancy.