TF and central nervous system cancer: We and others have reported that TWIST1 (TW), a bHLH transcription factor (TF) and master regulator of epithelial‐to‐mesenchymal transition (EMT), is associated with increased glioma grade and promotes invasion and glioma stem cell (GSC) phenotypes (Elias et al., 2005; Mikheeva et al., 2010; Rahme and Israel, 2015).