In addition, in a Cre‐Lox TW mouse glioma model we found that TW deletion inhibited tumorigenicity when neural progenitor cells (NPCs) were transformed with Ha‐RASV12 overexpression and p53 knockdown but not with co‐overexpression of Ha‐RASV12 and myristoylated AKT (a constitutively phosphorylated form) (Mikheev et al., 2017). This evidence concerns the gene AKT1 and central nervous system cancer.