HIF1A and diabetes mellitus: The globular shape of the diabetes-exposed Hif1a+/− heart was indicated by the ratio of the left–right axis (width) and the apical-basal axis (length) of the heart (mean ratio = 1.03) compared to the normal shaped hearts of unexposed Wt and Hif1a+/−, and diabetes-exposed Wt (mean ratio = 1.38, 1.39, and 1.38, respectively).