Among the top 18 miRNAs of which the predictive binding scores were higher than 0.9 (Additional file 3: Figure S1), miR-335-5p and miR-1972 stroke our sight because DANCR and ROCK1 shared the similar miRNA response elements (MREs) for miR-335-5p and miR-1972 (Fig. 4a, predicted by DIANA-LncBase and TargetScan). The gene discussed is ROCK1; the disease is stroke disorder.