Reports have shown the ZFX expression in both cytoplasm and the nucleus of human glioma cell lines[35], colorectal cancer tissues[37], and tongue squamous cell carcinoma tissues, but only cytoplasmic signal has been detected in renal cell carcinoma tissues[38], and only a nuclear signal has been identified in normal samples of tongue tissues[39]. This evidence concerns the gene ZFX and hereditary clear cell renal cell carcinoma.