These included BMI (from 1 to 18 years); fat and lean mass (from 9 to 18 years); systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse rate and glucose (from 7 to 18 years); triglycerides, high density lipoprotein cholesterol (HDL-c) and non-HDL-c (from birth to 18 years); c-reactive protein (CRP) (from 9 to 18 years) and measures of sub-clinical cardiovascular disease (carotid-femoral pulse wave velocity (PWV), left ventricular mass index (LVMI) and carotid intima media thickness (cIMT)) at age 18 years. The gene discussed is CRP; the disease is cardiovascular disorder.