Chronic isoproterenol treatment fails to induce cardiac hypertrophy in PKA inhibitor peptide transgenic mice (Zhang et al. 2013).Ang II induced hypertension in both PKA Cβ-null mice and their WT littermates (Feng et al. 2017), but PKA Cβ-null mice are resistant to a number of Ang II-induced cardiopathological effects observed in wild-type mice, including hypertrophy, decreased diastolic performance, and enlarged left atria (Enns et al. 2010). Here, AGT is linked to hypertensive disorder.