In this study, we did not observe a pattern of tau histopathology in AD (i.e., with coincident Aβ pathology, n = 113) that was clearly distinct from cases considered to represent “definite PART” (Aβ phase 0, n = 134), and seeding activity was similar in both groups across the TRE/EC, LC, STG, and primary VC. Here, MAPT is linked to Alzheimer disease.