With respect to AURKA, unlike the findings of Pan et al.48, who reported that it could destruct bipolar spindle structure, suppress tumor growth and induce cell apoptosis in OSCC, no significant change in AURKA expression was observed in our study (Fig. 5a, e, f), indicating it was not mediated by PRC1 in OSCC or other pathways, such as the co-binding of proteins that induces effects to those observed during mitosis. This evidence concerns the gene AURKA and neoplasm.