Unlike the findings of Zhang et al.34 that PRC1 knockdown in two gastric carcinoma cell lines, AGS and HGC27, induced apoptosis, no significant difference in apoptosis was observed in HSC-2 and Cal-27 cells treated with si-PRC1 at prophase or telophase (Fig. 3d), demonstrating that the effect of PRC1 on cell apoptosis is highly tissue and tumor-specific. This evidence concerns the gene PRC1 and neoplasm.