In the case of FGFR2, altered isoform switching and aberrant expression of the mesenchymal FGFR2c isoform in epithelial cells induce epithelial-mesenchymal transition (EMT)5,6 and are involved in cancerogenesis7,8, while the epithelial FGFR2b variant appears to exert tumor suppressive functions9,10. This evidence concerns the gene FGFR2 and neoplasm.