Given that ALDH1 is believed to be a major contributor to the enhanced ALDH activity in ovarian cancer33, and high ALDH activity plays a critical role in maintenance of the CSC subpopulation24, we reasoned that DDB2 silencing may promote ovarian cancer cell dedifferentiation by enhancing ALDH1A1 expression. Here, ALDH1A1 is linked to ovarian carcinoma.