Besides CD44+CD117+ cells, we have also demonstrated that ALDH+ cells isolated from the ovarian cancer cell line 2008 have all known CSC properties including high tumor-initiating capacity (Supplementary Figure S2), and DDB2 silencing is able to increase the ALDH+ cell population in these cells (Supplementary Figure S1b, c, e and f). The gene discussed is LDHA; the disease is neoplasm.