Our previous report on the protection of PEDF on DKO rd8 (Ccl2-/-/Cx3cr1-/- on C57BL/6 N [Crb1rd8]) mice, a model for progressive, focal retinal degeneration, agrees with data in the present study by showing lower levels of BAX protein, higher levels of BCL2 protein, decrease in cell death and attenuation of focal retinal lesions in the PEDF-treated retina20. The gene discussed is CX3CR1; the disease is retinal degeneration.