We recently showed that peptides derived from the domain of human PEDF protein that confer the functions associated with neuronal differentiation and survival (residues 98–114) are strongly neuroprotective when injected into the eye of a murine model of retinal degeneration, the retinal degeneration 1 (rd1) mouse, and act through PEDF-R11. Here, SERPINF1 is linked to retinal degeneration.