To confirm the significance of immunological modulation in the treatment of HER2-amplified BC and TNBC, the GeparSixto phase II clinical trial by Denkert et al. [48] evaluated immune-specific mRNA markers, such as immune-activating chemokines and immunosuppressive checkpoint molecules, in the tumors of 481 patients treated with neoadjuvant chemotherapy with or without carboplatin. Here, ERBB2 is linked to breast cancer.