ERBB2 and breast cancer: One of two antibody-drug conjugate treatments approved by the FDA, trastuzumab emtansine (T-DM1) (the other being brentuximab vedotin in Hodgkin’s Lymphoma) was successfully tested and shown to be more effective and less toxic than lapatinib plus chemotherapy, second line treatment for advanced HER2-postive BC in the EMELIA Trial [17].