These alterations did not respond to dialysis treatment (Kt/V, according to the Daugirdas 2 formula was always over 1.7); he did not take Cinacalcet, as prescribed, and his PTH decreased only partially during dialysis, in spite of hypercalcemia at the end of treatment (1604 ng/l before to 1087 ng/l after dialysis, in spite of a total calcium increase from 2.49 mmol/l to 2.90 mmol/l at the end of dialysis), suggesting secondary-tertiary hyperparathyroidism. The gene discussed is PTH; the disease is Hypercalcemia.