The role of ATP6AP2-over/underexpressed ADSCs should also be clarified during differentiation into other lineages of cells (hepatocytes, nephron progenitor cells, cardiomyocytes, etc.)in a perspective of cell therapy; for example, cardiovascular diseases where hypertension and hypercholesterolemia were correlated with the RAS components [59, 25], which in turn were associated with ATP6AP2. The gene discussed is ATP6AP2; the disease is hypertensive disorder.