Because the interaction between the LTBP2 and the Fibrillin-1 proteins is close to this LTBP2 C-terminal region, we could speculate that the instability of the zonular fibers characteristic in microspherophakia is due to the loss of the association between these two proteins. This evidence concerns the gene LTBP2 and glaucoma secondary to spherophakia/ectopia lentis and megalocornea.