The previous models are sterile models, and observations in CLP, which is considered as the golden standard for human polymicrobial sepsis [75], or in colon ascendens stent peritonitis (CASP) left the scientific community with contradictory results regarding the different roles of TNFR1 and TNFR2 in real sepsis models. Here, TNFRSF1A is linked to Sepsis.