Selective TNFR1 targeting is described for dry-skin induced chronic itching [412], neuropathic pain [136], ventilator-induced acute lung injury [356], eye disorders [203], and cardiomyopathy and myocardial ischemic injury [413,414,415,416], and this list is not limited to these examples. The gene discussed is TNFRSF1A; the disease is Pruritus.