There is evidence showing that polymorphisms in ANRIL can interfere in its interaction with p14, 15, and p16, affecting the expression of these proteins and, in consequence, affecting the PRC complex role, therefore influencing progression to some diseases and contributing, for example, to coronary artery disease (CAD) susceptibility [78,79]. The gene discussed is CDKN2B-AS1; the disease is coronary artery disorder.