DISC1 and major depressive disorder: Furthermore, translocations in the disrupted in schizophrenia (DISC) genome locus, including DISC1 (which encodes the scaffold protein DISC1) and DISC2, a lncRNA antisense to DISC1, have been linked with various psychiatric disorders, such as schizophrenia (SZ), autistic spectrum disorders (ASD), major depression disorder (MDD), among others [174,175].