MAPT and Alzheimer disease: Previously, changes were observed in the oligodendrocytes and myelin of mice after amyloid plaques and tau were introduced [21] and the aforementioned findings were expanded on; In this recent study, it was discovered that oligodendrocyte development is atypical in these mice [20], suggesting that the mice might be a valid model for AD in humans, because the progression of AD in humans is also not a normal part of aging.