For example, Apolipoprotein E4 (Apo E4) is a genetic risk factor for late onset AD, and one study investigated three main compounds in TCM, solapalmitine, isodesacetyluvaricin, and budmunchiamine L5, that, based on the results of virtual drug screening, have the ability to inhibit Apo E4 [49]. The gene discussed is APOE; the disease is Alzheimer disease.