The combined analysis of different histotypes regarding IDH and TERTp mutational status led to the conclusion that TERTp mutations are more prevalent in IDH-wildtype tumours, such as in GBs (72% in IDH-wildtype vs. 24% in IDH-mutated tumours) and anaplastic astrocytomas (AA) (47% vs. 11%); diffuse astrocytomas present a smaller variation (26% vs. 16%). Here, IDH1 is linked to diffuse astrocytoma.