A recent study by Fogli et al. [302] reported the presence of ALT in high-grade gliomas associated with IDH1/2 mutation, O-6-Methylguanine-DNA Methyltransferase (MGMT) methylation, absence of functional ATRX protein and elevated TERRA levels, supporting the need for more studies in these tumours, since their molecular background seems to have major importance in the stratification of patient prognosis. The gene discussed is ATRX; the disease is central nervous system cancer.