LTRIN was shown to facilitate the transmission of ZIKV by interfering with lymphotoxin signaling; LTRIN directly interacts with the lymphotoxin-β receptor (LTβR) and inhibits its activation [106], thereby affecting host defense as LTβR signaling plays a key role in defending against bacterial, virus and parasite infections [107]. The gene discussed is LTBR; the disease is parasitic infectious disease.