Polycystin 1 (PC1) and polycystin 2 (PC2), the defect proteins in ADPKD, are found in both vascular smooth muscle cells (VSMC) and endothelial cells that are involved in all major vessels including the aorta and intracranial arterials [4,5,6]. This evidence concerns the gene PKD1 and autosomal dominant polycystic kidney disease.