SOD1 and amyotrophic lateral sclerosis: It is obvious that all the “roles” of SOD1 are crucial to address the course of the disease; thus, in turn, helping in isolating the role of SOD1 in ALS disease could open new scenarios to develop new and promising therapies, i.e., ASO or the delivery of nanoparticles, for ALS in particular to design innovative pharmaco-therapies using ASOs, siRNAs and CRISPR to counteract ALS.