SOD1 and amyotrophic lateral sclerosis: Indeed, we proved that in PBMCs of a sub-group of sALS patients, SOD1 was present in the nuclear compartment at higher levels; while perinuclear/cytoplasm SOD1 aggregates were found in the remaining ALS subjects [53], thus suggesting a possible relationship between the presence of protein aggregates and SOD1 enrichment in the insoluble fraction.