On the contrary, we [22] and other authors [23] had shown that the combination therapy (IFN or PEG-IFN and ribavirin) is effective in HCV-positive indolent NHL of different histologies (including lymphocytic lymphoma, marginal-zone lymphoma, lympho-plasmacytic lymphomas and even follicular lymphomas): in these cases, it is likely that the anti-proliferative properties of IFN played the leading role in the cure of lymphoproliferative diseases rather than its antiviral properties. This evidence concerns the gene IFNA1 and follicular lymphoma.