Interestingly, Treg cells were also recently shown to be highly sensitive to oxidative stress in the tumor microenvironment, due in this case to a weak nuclear factor (erythroid-derived 2)-like 2 (NRF2)-associated antioxidant system [59], which may explain our observation of reduced Treg accumulation (Fig 1C). Here, NFE2L2 is linked to neoplasm.