CD4 and neoplasm: Moreover, consistent with the fact that IFN-γ+ cells (S3A Fig), CD4+, and CD8+ T cells (Fig 2B) are not affected by neutrophil depletion in vivo, we found that neutrophils from tumor-bearing mice preferentially impacted the in vitro proliferation of CD27− γδ T cells when compared to CD27+ γδ, CD4+, and CD8+ T cells (S5A Fig).