S100A8 and neoplasm: For example, KEP tumor-induced neutrophils were immature and expressed c-kit protein and S100 calcium-binding protein A8 (s100a8) transcript, which are molecules associated with pro-metastatic features [11]; in contrast, peritoneal B16 tumor–induced neutrophils did not express c-kit or up-regulated s100a8 when compared to neutrophils from the bone marrow of tumor-free mice.