NOS2 and breast cancer: In fact, Coffelt and colleagues recently proposed, in a transplantable model K14cre;Cdh1F/F;Trp53F/F (KEP) of mammary tumor-bearing mice, a link between Vγ4+ γδ17 T cells and neutrophils that led to inducible nitric oxide synthase (iNOS)-dependent suppression of cytotoxic CD8+ T cells and promoted lung metastases [11].