In various cell lines, including the murine Neuro2a (N2A) and human SHEP NB cell lines enforced expression of the internal caspase-generated fragment TrkC 496–641 (named TrkC-KF) was associated with cell death induction, while TrkC 1–495 and TrkC 642–825 displayed no proapoptotic activity [9, 13]. This evidence concerns the gene NTRK3 and neuroblastoma.