LMNA and Hutchinson-Gilford progeria syndrome: MADA can show a high degree of clinical variability where some homozygous LMNA MADA mutations result in phenotypes that overlap with Hutchinson-Gilford progeria syndrome (HGPS) (p.S573L) and EDMD with progeroid features (p.R471C); 85% of MADA cases caused by LMNA mutations are homozygous for a change at the p.527 residue (112).