There is an additional risk reduction with ACE inhibitors and β -blockers over and above that associated with lowering of blood pressure among diabetics.12 However, the use of ACE inhibitors/ ARBs among those who knew their status was in only one-third of all participants, yet we know that ACE inhibitors reduce the risk for nephropathy and other complications of diabetes, such as LVH. This evidence concerns the gene ACE and kidney disorder.