PGP and adenocarcinoma: This result corresponds to the results obtained by Kulbacka et al. (2014) on different human adenocarcinoma cell lines with overexpression of P-glycoprotein and murine macrophage cells which revealed that electrochemotherapy with doxorubicin induces changes in P-gp expression and affects cellular ultrastructure; hence the most visible effect concerned resistant cell lines with P-gp overexpression [31].