With a different set of CLL samples than that used in Figure 4(b), rituximab and obinutuzumab significantly enhanced NK cell-mediated cytotoxicity by 31% and 45%, respectively, and the significance of ADCC, which is equivalent to this enhancement, was maintained in combination with the investigated irreversible BTK inhibitors at clinically relevant concentrations of 1 μM. Significant impairment of ADCC was observed in combinations of rituximab with ibrutinib and tirabrutinib but not acalabrutinib and did not occur in the tested combinations with obinutuzumab. Here, BTK is linked to B-cell chronic lymphocytic leukemia.