Also with the second-generation of irreversible BTK inhibitors, the ADCC of obinutuzumab against CLL cells was less impaired than that of rituximab, in agreement with reports about the interference of acalabrutinib or tirabrutinib with the ADCC of anti-CD20 mAbs against Mec1 or SUDHL-4 cells, respectively [25]. Here, ATR is linked to B-cell chronic lymphocytic leukemia.