For genotypic comparison, patients with different Gleason grades (based on degree of differentiation between cells, low grade < 7 and high grade > 7), clinical stages [based on international tumor-node-metastasis (TNM) system for PCa, localized and advanced], and PSA levels (PSA ≤ 20 ng/ml and PSA > 20 ng/ml) were subcategorized into 2 subgroups. This evidence concerns the gene KLK3 and posterior cortical atrophy.