By interfering with the PP2A‐mediated dephosphorylation, SET abolishes the tumor suppressor functions of PP2A and activates oncogenic signaling such as Akt, Erk, c‐Jun, c‐Myc, and β‐catenine to promote the survival and progression of cancer cells.15, 33, 35, 36, 37. This evidence concerns the gene PTPA and cancer.