Additionally, SET epigenetically represses miR‐30c that serves as a direct regulator of the crosstalk between ROCK7/RAC1 and cofilin.42 SET protein also forms the SET complex together with protein pp32, HMGB‐2, Ape‐1, Trex 1, and NM23H1.23 NM23H1 is a well‐known DNase and tumor metastasis suppressor.43 SET is able to bind to NM23H1 and inhibits its activity to break DNA to single strand nicks. This evidence concerns the gene NME1 and neoplasm.