SET and B-cell chronic lymphocytic leukemia: For example, in chronic myeloid leukemia (CML) cells, SET protein was overexpressed and further upregulated during blast crisis.9 A similar phenomenon was observed in B‐cell chronic lymphocytic leukemia (CLL), non‐Hodgkin lymphoma (NHL), and acute myeloid leukemia (AML) at both mRNA and protein levels.