It was designed by fusing a protein transduction domain derived from the Drosophila antennapedia protein to the peptide COG133 which is mimetic peptide created from amino acid residues 133‐149 of the Apolipoprotein E (apoE) holoprotein.74 COG112 inhibits inflammatory response in Colitis by suppression of NF‐κB signaling and proinflammatory cytokine expression. This evidence concerns the gene APOE and colitis.