KCs regulate the immune homeostasis after liver transplantation and KCs M2 polarization contributes to the extension of liver allograft survival.11, 31 A recent study shows that sFGL2 increases the frequency of glioma‐associated M2 macrophages in mice.24 Consistent with this finding, our in vitro results showed that sFGL2 could polarize M1 KCs induced by LPS/IFN‐γ toward the M2 phenotype. The gene discussed is TBCE; the disease is central nervous system cancer.