Additionally, it was found that the altered expression of PODXL lead to the molecular changes (e.g., vimentin, E-cadherin, collagen I) associated with TGF-β induced EMT of human lung adenocarcinoma cells [14], demonstrating the significant role of PODXL in the EMT and metastasis of cancers. This evidence concerns the gene CDH1 and lung adenocarcinoma.