Multiple studies have reported significant increases in circulating IL-6 and sIL-6R in patients with IBD, albeit in different concentration ranges (Supplementary Table 1), as well as positive associations between IL-6 and sIL-6R serum levels and both activity indices and biomarkers of IBD [9, 11, 23, 25, 28, 29]. The gene discussed is IL6R; the disease is inflammatory bowel disease.