In a study by Zhao et al. in 2586 Chinese adult individuals, the authors found that two single-nucleotide polymorphisms (SNPs; rs2576178 GG genotype and rs2296545 CC) within the renalase gene were associated with essential hypertension (defined as BP ≥ 160/100 mmHg) [15]. The gene discussed is RNLS; the disease is essential hypertension.