For example, a therapy targeting CDK1/2, which has entered clinical trials to treat colon cancer and acute leukemia, abrogates G2/M transition and induces G2 suppression37, 38; tetraploidy checkpoint and hippo tumor suppressor pathway determine the fate of mitotic slipped cells at G1 phase4, 5, 39, 40. The gene discussed is CDK1; the disease is malignant colon neoplasm.