RB1 and cancer: These included 11 cell cycle regulators (CDKN2D, CDC42EP4, GADD45A, MGMT, GADD45B, CCDC34, CDC42EP3, CDKN1B, CCN1, CDC42BPA, and CDKN2C), 10 tumour suppressor genes (HIC1, BGN, RB1, RASSF1, LATS1, PTEN, P53, ITIH5, PSAT1, and ACTG2), two methylation specific genes (DNMT3a and MeCP2), one gene associated with aberrant expression in cancer (BPGM), and one gene functionally associated with the biosynthesis of sex steroids (HSD17B7).